| Eastern Airways | Leeds-Bradford | Operating |
| Loganair | Manchester | Operating |
| Loganair | Aberdeen | Operating via Manchester |
| Loganair | Teesside | Operating |
| Loganair | Edinburgh | Operating |
| Skybus | Isles of Scilly | Operating - finishes 23rd Oct |
| Eastern Airways | Teesside | Operating - finishes 29th Oct |
| Loganair | Newcastle | Operating |
| easyJet | Manchester | Operating - finishes 30th Oct |
| easyJet | Glasgow | Finished 2021 season on 4th Sept |
| Aer Lingus | Dublin | Not operating |
| Ryanair | Faro | Operating - due to finish 30th Oct |
| Ryanair | Alicante | Operating |
| easyJet | London Gatwick | Finished 2021 season on 28th September |
| British Airways | London Heathrow | Finished 2021 season on 4th September |
| Unconfirmed | London (Airport not confirmed) | PSO route to London announcement expected October 2021 |
| Blue Islands | Jersey and Guernsey | Finished 2021 season on 1st Sept |
| BACityFlyer | Belfast City | Finished 2021 season on 28th August |
| Edelweiss | Zurich | Will not operate in 2021 |
| Eurowings | Dusseldorf | Will not operate in 2021 |
| Aer Lingus | Cork | Not operating |
| SAS | Copenhagen | Will not operate in 2021 |
| easyJet | Birmingham | Finished 2021 season on 11th Sept |
| easyJet | Inverness | Finished 2021 season on 12th Sept |